I recently implemented a server side anti-virus solution using ClamAV. This is a freeware utility, mostly with Linux and Unix variants, but there is also a pre-packaged Windows build. It has no problem running on server.
So now, in addition to using avast! Home on my Windows workstation, I’ve also got postfix scanning every incoming (and outgoing) email message and silently deleting anything that’s infected.
I finally got fed up with seeing infected email messages in my inbox. Even though avast! properly detected them and marked them as infected – it was still a pain seeing them in the first place. (I also wanted to have a more “backend” solution to everything in general.) After doing a bit of hunting around, I was happy to stumble across ClamAV.
In combination with ASSP, this now means that I’m working towards finally having an email solution that will only deliver to me (and anybody else who’s email gets to them via Virgil, my server) legitimate, virus free messages.